Zolpidem

Name: Zolpidem
Brand: Tocris Bioscience
SKU: 0655

Tocris Bioscience, part of Bio-Techne | Catalog # 0655

Citations (7)

COA / SDS

Benzodiazepine agonist

Discontinued Product

0655 has been discontinued. View all GABA-A Receptor Benzodiazepines products.

Key Product Details

Description:	Benzodiazepine agonist
Chemical Name:	N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
Purity:	≥99% (HPLC)
Molecular Weight:	307.39

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Technical Data
Citations

Biological Activity for Zolpidem

Benzodiazepine agonist with high selectivity for α1-subunit-containing GABA_A receptors (BZ/ω₁ site) and very high intrinsic activity. K_i values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABA_A receptors respectively. Hypnotic that does not induce physical dependence.

Technical Data for Zolpidem

M. Wt	307.39
Formula	C₁₉H₂₁N₃O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	82626-48-0
PubChem ID	5732
InChi Key	ZAFYATHCZYHLPB-UHFFFAOYSA-N
Smiles	O=C(N(C)C)CC1=C(C3=CC=C(C)C=C3)N=C2N1C=C(C)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Zolpidem

References are publications that support the biological activity of the product.

Soderhielm Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABA_A receptors. Biochem.Pharmacol. 2018 PMID: 30121248
Perrault Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zol. J.Pharmacol.Exp.Ther. 1992 PMID: 1403792
Crestani Mechanism of action of the hypnotic zol. in vivo. Br.J.Pharmacol. 2000 PMID: 11090095
Depoortere Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 1986 PMID: 2871178
Arbilla High affinity [³H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 1986 PMID: 2878820

Zolpidem

Tocris Bioscience, part of Bio-Techne | Catalog # 0655

Key Product Details

Biological Activity for Zolpidem

Technical Data for Zolpidem

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Zolpidem

Product Documents for Zolpidem

COA

Certificate of Analysis

SDS

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