ZIP
Tocris Bioscience, part of Bio-Techne | Catalog # 2549
Cell-permeable inhibitor of atypical PKC isozyme PKMζ
Key Product Details
Description
Cell-permeable inhibitor of atypical PKC isozyme PKMζ
Alternative Names
z-Pseudosubstrate inhibitory peptide
Product Description
ZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.Control Peptide and Biotinylated Peptide also available.
Product Specifications
Molecular Weight
1928.40
Formula
C90H154N30O17
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
863987-12-6
PubChem ID
16156119
InChI Key
CRKARHQCXWSUMV-HOHDCHNJSA-N
SMILES
[H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Pastalkova Storage of spatial information by the maintenance mechanism of LTP. Science 2006 PMID: 16931766
- Ling Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci.
- Serrano Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 2005 PMID: 15728837
Product Specific Notices for ZIP
For research use only
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