ZIP

Name: ZIP
Brand: Tocris Bioscience
SKU: 2549

Catalog # 2549 | Tocris Bioscience a Bio-Techne Brand

Citations (8)

COA / SDS

Cell-permeable inhibitor of atypical PKC isozyme PKMζ

Key Product Details

Description:	Cell-permeable inhibitor of atypical PKC isozyme PKMζ
Alternative Names:	z-Pseudosubstrate inhibitory peptide
Purity:	≥95% (HPLC)
Molecular Weight:	1928.4

View Full Technical Details for ZIP

Technical Data
Citations (8) / Reviews

Biological Activity for ZIP

ZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC₅₀ = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Control Peptide and Biotinylated Peptide also available.

Technical Data for ZIP

M. Wt	1928.4
Formula	C₉₀H₁₅₄N₃₀O₁₇
Single Letter Sequence	SIYRRGARRWRKL (Modifications: Ser-1 = Myr-Ser)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	863987-12-6
PubChem ID	16156119
InChi Key	CRKARHQCXWSUMV-HOHDCHNJSA-N
Smiles	[H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZIP

Solubility

Soluble to 1mg/ml in water

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References for ZIP

References are publications that support the biological activity of the product.

Pastalkova Storage of spatial information by the maintenance mechanism of LTP. Science 2006 PMID: 16931766
Serrano Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 2005 PMID: 15728837
Ling Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci.

Citations for ZIP (8)

Showing 1 - 8 of 8 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for ZIP include:

Awasthi et al. (2019) Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science. 363
PMID: 30545844
Mirza et al. (2017) Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight. 2
PMID: 29093271
Han et al. (2015) Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury. J Neurophysiol. 2015:601767
PMID: 26457205
Chen et al. (2015) Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity. Mol Pain. 113:3047
PMID: 25761958
Grosso et al. (2015) The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli. Nat Commun. 6:8886
PMID: 26619940
Lee et al. (2013) Prkcz null mice show normal learning and memory. Nature. 493:416
PMID: 23283171
Laferrière et al. (2011) PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain. Autophagy. 7:99
PMID: 22185613
Balaban et al. Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix. Front Cell Neurosci. 9:222
PMID: 26157359

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