ZD 9379

Name: ZD 9379
Brand: Tocris Bioscience
SKU: 3322

Tocris Bioscience, part of Bio-Techne | Catalog # 3322

COA / SDS

Brain penetrant NMDA antagonist; acts at glycine site

Discontinued Product

3322 has been discontinued. View all NMDA Receptor Antagonists products.

Key Product Details

Description:	Brain penetrant NMDA antagonist; acts at glycine site
Chemical Name:	7-Chloro-2,3-dihydro-2-(4-methoxy-2-methylphenyl)pyridazino [4,5-b] quinoline-1,4,10(5H)trione
Purity:	≥98% (HPLC)
Molecular Weight:	383.79

View Full Technical Details for ZD 9379

Technical Data
Citations

Biological Activity for ZD 9379

ZD 9379 is a NMDA receptor antagonist; acts at glycine site. Neuroprotective; reduces infarct size and frequency of spreading depressions in a rat model of ischemic stroke. Brain penetrant.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Technical Data for ZD 9379

M. Wt	383.79
Formula	C₁₉H₁₄ClN₃O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	170142-20-8
PubChem ID	9843028
InChi Key	PSTDMIAVUUYOOQ-UHFFFAOYSA-N
Smiles	O=C2C3=C(C(NN(C4=C(C)C=C(OC)C=C4)C3=O)=O)NC1=CC(Cl)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ZD 9379

References are publications that support the biological activity of the product.

Takano Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke. 1997 PMID: 9183359
Tatlisumak A glycine antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Acta.Neurochir.Suppl. 2000 PMID: 11450037
Bare Pyridazino[4,5-b]quinolinediones: a series of novel glycine site NMDA antagonists with potent in vitro and in vivo properties. Abstracts of Papers of the ACS