Z-VRPR-FMK trifluoroacetate salt

Name: Z-VRPR-FMK trifluoroacetate salt
Brand: Tocris Bioscience
SKU: 4645

Tocris Bioscience, part of Bio-Techne | Catalog # 4645

Citations (5)

COA / SDS

Irreversible MALT1 inhibitor

Discontinued Product

4645 has been discontinued. View all MALT1 products.

Key Product Details

Description:	Irreversible MALT1 inhibitor
Purity:	≥95% (HPLC)

View Full Technical Details for Z-VRPR-FMK trifluoroacetate salt

Technical Data
Citations

Biological Activity for Z-VRPR-FMK trifluoroacetate salt

Z-VRPR-FMK trifluoroacetate salt is an irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.

This peptide is supplied in gross weight.

Licensing Information

Sold under licence from UNIL under the licenced patents

Important Information

This product is sold as a TFA salt. The stoichiometry of the salt and hydration levels vary from batch to batch. This product is sold in gross weight with the batch specific Net Product Content (free base) available on the Certificate of Analysis.

Technical Data for Z-VRPR-FMK trifluoroacetate salt

Formula	C₃₁H₄₉FN₁₀O₆.xCF₃CO₂H
Single Letter Sequence	VRPR (Modifications: Val-1 = Z-Val, Arg-4 = DL-Arg-fluoromethylketone)
Storage	Store at -20°C
Purity	≥95% (HPLC)
PubChem ID	121513848
InChi Key	WIPHXOQUHDJLCU-WTJMUODPSA-N
Smiles	OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF
M. Wt	676.79 (Free Base)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Z-VRPR-FMK trifluoroacetate salt

References are publications that support the biological activity of the product.

Rebeaud The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 2008 PMID: 18264101