YK 4-279

Name: YK 4-279
Brand: Tocris Bioscience
SKU: 4067

Tocris Bioscience, part of Bio-Techne | Catalog # 4067

Citations (3)

COA / SDS

Inhibitor of RNA helicase A (RHA)

Key Product Details

Description:	Inhibitor of RNA helicase A (RHA)
Chemical Name:	4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	366.2

View Full Technical Details for YK 4-279

Technical Data
Citations

Biological Activity for YK 4-279

YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Inhibits Ewing's sarcoma family tumor (ESFT) cell growth; induces apoptosis.

Compound Libraries for YK 4-279

YK 4-279 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YK 4-279

M. Wt	366.2
Formula	C₁₇H₁₃Cl₂NO₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1037184-44-3
PubChem ID	44632017
InChi Key	HLXSCTYHLQHQDJ-UHFFFAOYSA-N
Smiles	O=C2NC1=C(Cl)C=CC(Cl)=C1C(CC(C3=CC=C(OC)C=C3)=O)2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YK 4-279

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.62	100

Preparing Stock Solutions for YK 4-279

The following data is based on the product molecular weight 366.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.65 mL	27.31 mL
5 mM	0.55 mL	2.73 mL	5.46 mL
10 mM	0.27 mL	1.37 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for YK 4-279

References are publications that support the biological activity of the product.

Erkizan Small molecule selected to disrupt oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits Ewing's sarcoma. Nat.Med. 2009 PMID: 19584866