WQ 1
Tocris Bioscience, part of Bio-Techne | Catalog # 7156
Potent and selective σ1 receptor antagonist; active in vivo
Key Product Details
Description
Potent and selective σ1 receptor antagonist; active in vivo
Alternative Names
TC WQ 1,TC Sigma1
Product Description
WQ 1 is a high affinity and selective σ1 receptor antagonist (pKi values are 10.28-10.85, 5.81-6.53 and 5.80 at σ1, σ2 and DAT). Displays σ1/σ2 selectivity ratio of 29512. Selectively blocks binge eating without a general inhibition of food intake in rats.Product Specifications
Molecular Weight
337.48
Formula
C21H23NOS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2,3-Dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-4H-1-benzothiopyran-4-one
CAS Number
1204401-49-9
InChI Key
XWMHOCDNGHEUMF-UHFFFAOYSA-N
SMILES
O=C(C1=CC=CC=C1S2)CC2C3CCN(CC4=CC=CC=C4)CC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.87 | 50 | |
| Ethanol | 3.37 | 10 |
Preparing Stock Solutions
for WQ 1
The following data is based on the product molecular weight 337.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.93 mL | 29.63 mL | 59.26 mL |
| 2.5 mM | 1.19 mL | 5.93 mL | 11.85 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
| 25 mM | 0.12 mL | 0.59 mL | 1.19 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Piergentili Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J.Med.Chem. 2010 PMID: 20067271
- Bello Investigation of the role of chirality in the interaction with σ receptors and effect on binge eating episode of a potent σ 1 antagonist analogue of spipethiane. ACS Chem.Neurosci. 2019 PMID: 31298830
Product Specific Notices for WQ 1
For research use only
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