VH 032 amide-PEG2-alkyne

Tocris Bioscience, part of Bio-Techne | Catalog # 6684

VHL ligand with PEG linker and terminal alkyne for onward chemistry
Discontinued Product
6684 has been discontinued. View all Degrader Building Blocks products.

Key Product Details

Description

VHL ligand with PEG linker and terminal alkyne for onward chemistry

Alternative Names

(S,R,S)-AHPC-PEG2-Alkyne

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Product Description

VH 032 amide-PEG2-alkyne is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus PEG2 linker with terminal alkyne ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 6

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications

Molecular Weight

614.75

Formula

C31H42N4O7S

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

2098799-80-3

PubChem ID

132045744

InChI Key

HHXQNDSXTCIWSG-CERRFVOPSA-N

SMILES

CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOCC#C)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for VH 032 amide-PEG2-alkyne

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VH 032 amide-PEG2-alkyne

For research use only

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