Vatalanib succinate
Tocris Bioscience, part of Bio-Techne | Catalog # 5680
Potent VEGFR inhibitor; also aromatase inhibitor
Key Product Details
Description
Potent VEGFR inhibitor; also aromatase inhibitor
Alternative Names
CGP 79787D,PTK787/ZK222584
Product Description
Vatalanib succinate is a potent VEGFR inhibitor (IC50 values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs in vitro and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-β, c-Kit and c-Fms. Potent aromatase inhibitor (IC50 = 50 nM). Orally available.Product Specifications
Molecular Weight
464.90
Formula
C20H15ClN4.C4H6O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate
CAS Number
212142-18-2
PubChem ID
151193
InChI Key
LLDWLPRYLVPDTG-UHFFFAOYSA-N
SMILES
ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42.OC(CCC(O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.49 | 100 |
Preparing Stock Solutions
for Vatalanib succinate
The following data is based on the product molecular weight 464.90
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.76 mL | 21.51 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.30 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wood PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000 PMID: 10786682
- Bold New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J.Med.Chem. 2000 PMID: 10956229
- Banerjee The vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 inhibits aromatase. Cancer Res. 2009 PMID: 19435899
Product Specific Notices for Vatalanib succinate
For research use only
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