UPF 648

Name: UPF 648
Brand: Tocris Bioscience
SKU: 4926

Tocris Bioscience, part of Bio-Techne | Catalog # 4926

Citations (3)

COA / SDS

Potent kynurenine 3-monooxygenase (KMO) inhibitor

Discontinued Product

4926 has been discontinued. View all Hydroxylase Inhibitors products.

Key Product Details

Description:	Potent kynurenine 3-monooxygenase (KMO) inhibitor
Chemical Name:	(1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	259.09

View Full Technical Details for UPF 648

Technical Data
Citations

Biological Activity for UPF 648

UPF 648 is a potent kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (IC₅₀ = 20 nM). Increases kynurenic acid levels, and decreases 3-HK and QUIN levels in cerebrum and liver of neonatal rodents. Neuroprotective in a Drosophila model of Huntington's disease.

Technical Data for UPF 648

M. Wt	259.09
Formula	C₁₁H₈Cl₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	213400-34-1
PubChem ID	9859947
InChi Key	ZBRKMOHDGFGXLN-BQBZGAKWSA-N
Smiles	[H][C@]1([C@@H]([C@](O)=O)C1)C(C2=CC=C(Cl)C(Cl)=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for UPF 648

References are publications that support the biological activity of the product.

Campesan The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease. Curr.Biol. 2011 PMID: 21636279
Amaral Structural basis of kynurenine 3-monooxygenase inhibition. Nature 2013 PMID: 23575632
Amori On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J.Neurochem. 2009 PMID: 19226371
Ceresoli-Borroni Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J.Neurosci.Res. 2007 PMID: 17279543

UPF 648

Tocris Bioscience, part of Bio-Techne | Catalog # 4926

Key Product Details

Biological Activity for UPF 648

Technical Data for UPF 648

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for UPF 648

Product Documents for UPF 648

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

保持关注