UCL 2077

Tocris Bioscience, part of Bio-Techne | Catalog # 2661

Slow afterhyperpolarization (sAHP) channel blocker; sub-type selective Kv channel effects
Discontinued Product
2661 has been discontinued. View all Ca2+-Activated Potassium Channel Blockers products.

Key Product Details

Description

Slow afterhyperpolarization (sAHP) channel blocker; sub-type selective Kv channel effects

View all Ca2+-Activated Potassium Channel Blockers »

Product Description

UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker; reduces sAHP in hippocampal slice preparations. Displays no effect on Ca2+ currents or the time course of sAHP/sIAHP. Exhibits potent inhibition of KCNQ1 and KCNQ2, but differential effects at other KCNQs. Rescues memory retrieval in dopamine β-hydroxylase knockout mice.

Product Specifications

Molecular Weight

350.46

Formula

C25H22N2

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

N-Trityl-3-pyridinemethanamine

CAS Number

918311-87-2

PubChem ID

24868317

InChI Key

PQFNWDHABGBCHB-UHFFFAOYSA-N

SMILES

C(NC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)C1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.52 50
Ethanol 8.76 25

Preparing Stock Solutions for UCL 2077

The following data is based on the product molecular weight 350.46

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.71 mL 28.53 mL 57.07 mL
2.5 mM 1.14 mL 5.71 mL 11.41 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
25 mM 0.11 mL 0.57 mL 1.14 mL

Calculators

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Product Documents for UCL 2077

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for UCL 2077

For research use only

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