UCL 2077

Name: UCL 2077
Brand: Tocris Bioscience
SKU: 2661
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2661

(1)

Citations (85)

COA / SDS

Slow afterhyperpolarization (sAHP) channel blocker; sub-type selective Kv channel effects

Discontinued Product

2661 has been discontinued. View all Ca2+-Activated Potassium Channel Blockers products.

Key Product Details

Description:	Slow afterhyperpolarization (sAHP) channel blocker; sub-type selective Kv channel effects
Chemical Name:	N-Trityl-3-pyridinemethanamine
Purity:	≥99% (HPLC)
Molecular Weight:	350.46

View Full Technical Details for UCL 2077

Technical Data
Citations / Reviews (1)

Biological Activity for UCL 2077

UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker; reduces sAHP in hippocampal slice preparations. Displays no effect on Ca²⁺ currents or the time course of sAHP/sI_AHP. Exhibits potent inhibition of KCNQ1 and KCNQ2, but differential effects at other KCNQs. Rescues memory retrieval in dopamine β-hydroxylase knockout mice.

Technical Data for UCL 2077

M. Wt	350.46
Formula	C₂₅H₂₂N₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	918311-87-2
PubChem ID	24868317
InChi Key	PQFNWDHABGBCHB-UHFFFAOYSA-N
Smiles	C(NC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)C1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for UCL 2077

References are publications that support the biological activity of the product.

Zhang The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval. J.Neurosci. 2013 PMID: 23486971
Soh and Tzingounis The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol.Pharmacol. 2010 PMID: 20843955
Shah Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol.Pharmacol. 2006 PMID: 16877678

UCL 2077

Tocris Bioscience, part of Bio-Techne | Catalog # 2661

Key Product Details

Biological Activity for UCL 2077

Technical Data for UCL 2077

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for UCL 2077

Product Documents for UCL 2077

COA

Certificate of Analysis

SDS

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