TTP 22
Tocris Bioscience, part of Bio-Techne | Catalog # 4432
High affinity, selective CK2 inhibitor
Key Product Details
Description
High affinity, selective CK2 inhibitor
Product Description
TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor (IC50 = 0.1 μM, Ki = 40 nM). Displays selectivity for CK2 over JNK3, ROCK1 and MET (no inhibitory effects at 10 μM).Product Specifications
Molecular Weight
330.42
Formula
C16H14N2O2S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]propanoic acid
CAS Number
329907-28-0
PubChem ID
1536915
InChI Key
RAOULLCLLOGTDA-UHFFFAOYSA-N
SMILES
CC(C=C3)=CC=C3C1=CSC2=C1C(SCCC(O)=O)=NC=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.04 | 100 | |
| Ethanol | 6.61 | 20 |
Preparing Stock Solutions
for TTP 22
The following data is based on the product molecular weight 330.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.03 mL | 15.13 mL | 30.26 mL |
| 5 mM | 0.61 mL | 3.03 mL | 6.05 mL |
| 10 mM | 0.30 mL | 1.51 mL | 3.03 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Golub Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur.J.Med.Chem. 2011 PMID: 21276643
Product Specific Notices for TTP 22
For research use only
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