Tramiprosate

Name: Tramiprosate
Brand: Tocris Bioscience
SKU: 3619

Tocris Bioscience, part of Bio-Techne | Catalog # 3619

COA / SDS

Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog

Discontinued Product

3619 has been discontinued. View all Amyloid beta Peptides products.

Key Product Details

Description:	Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
Alternative Names:	Homotaurine
Chemical Name:	3-Amino-1-propanesulfonic acid
Molecular Weight:	139.17

View Full Technical Details for Tramiprosate

Technical Data
Citations

Biological Activity for Tramiprosate

Tramiprosate is a sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.

Technical Data for Tramiprosate

M. Wt	139.17
Formula	C₃H₉NO₃S
Storage	Store at +4°C
CAS Number	3687-18-1
PubChem ID	1646
InChi Key	SNKZJIOFVMKAOJ-UHFFFAOYSA-N
Smiles	NCCCS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Tramiprosate

References are publications that support the biological activity of the product.

Gervais Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis. Neurobiol.Aging 2007 PMID: 16675063
Santa-Maria Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol.Neurodegen.
Fariello Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology 1982 PMID: 7199633

Tramiprosate

Tocris Bioscience, part of Bio-Techne | Catalog # 3619

Key Product Details

Biological Activity for Tramiprosate

Technical Data for Tramiprosate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Tramiprosate

Product Documents for Tramiprosate

COA

Certificate of Analysis

SDS

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