TNP
Tocris Bioscience, part of Bio-Techne | Catalog # 3946
Inhibitor of IP6K; also inhibits IP3K
Discontinued Product
3946 has been discontinued.
View all Other Kinase Inhibitors products.
Key Product Details
Description
Inhibitor of IP6K; also inhibits IP3K
Product Description
TNP is a reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM).Product Specifications
Molecular Weight
443.38
Formula
C20H16F3N7O2
Storage
Store at +4°C
Purity
≥97% (HPLC)
Chemical Name
N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine
CAS Number
519178-28-0
PubChem ID
16760513
InChI Key
DDSBPUYZPWNNGH-UHFFFAOYSA-N
SMILES
O=[N+](C(C=C4)=CC=C4CNC1=C2C(NC=N2)=NC(NCC3=CC=CC(C(F)(F)F)=C3)=N1)[O-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.34 | 100 | |
| Ethanol | 11.08 | 25 |
Preparing Stock Solutions
for TNP
The following data is based on the product molecular weight 443.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chang Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem 2002 PMID: 12210991
- Padmanabhan Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J.Biol.Chem. 2009 PMID: 19208622
Product Specific Notices for TNP
For research use only
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