TM 5441

Tocris Bioscience, part of Bio-Techne | Catalog # 6194

Plasminogen activator inhibitor-1 (PAI-1) inhibitor
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Key Product Details

Description

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

View all PAI-1 Inhibitors »

Product Description

TM 5441 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 3.58 - 60.3 μM). Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and cardiac hypertrophy in mice. Renoprotective. Orally bioavailable.

Product Specifications

Molecular Weight

450.80

Formula

C21H16ClN2NaO6

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt

CAS Number

2319722-53-5

PubChem ID

44250349

InChI Key

RDKPAESSEMYFJL-UHFFFAOYSA-M

SMILES

O=C(C1=C(C=CC(Cl)=C1)NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)O[Na]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.08 100

Preparing Stock Solutions for TM 5441

The following data is based on the product molecular weight 450.80

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.09 mL 22.18 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Reconstitution Calculator

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Product Documents for TM 5441

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TM 5441

For research use only

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