TCS 46b

Name: TCS 46b
Brand: Tocris Bioscience
SKU: 2782

Tocris Bioscience, part of Bio-Techne | Catalog # 2782

Citations (7)

COA / SDS

GluN1A/GluN2B-selective NMDA antagonist; orally bioavailable

Discontinued Product

2782 has been discontinued. View all NMDA Receptor Antagonists products.

Key Product Details

Description:	GluN1A/GluN2B-selective NMDA antagonist; orally bioavailable
Chemical Name:	1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	345.44

View Full Technical Details for TCS 46b

Technical Data
Citations

Biological Activity for TCS 46b

TCS 46b is an orally active, subtype-selective GluN1A/GluN2B (formally NR1A/NR2B) NMDA receptor antagonist (IC₅₀ values are 5.3, 35000 and > 100000 nM for GluN1A/2B (NR1A/2B), GluN1A/2B (NR1A/2B) and GluN1A/2C (NR1A/2C) receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for TCS 46b

M. Wt	345.44
Formula	C₂₂H₂₃N₃O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	302799-86-6
PubChem ID	9863010
InChi Key	JJEXWPHPFZLTCU-UHFFFAOYSA-N
Smiles	O=C2NC1=CC=C(C#CCN3CCC(CC4=CC=CC=C4)CC3)C=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TCS 46b

References are publications that support the biological activity of the product.

Roger Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[¹¹C]one, as a potent NR_1A/2B subtype selective NMDA PET radiotracer. Bioorg.Med.Chem. 2003 PMID: 14642584
Wright Subtype-selective N-MthD.-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. J.Med.Chem. 2000 PMID: 10978188

TCS 46b

Tocris Bioscience, part of Bio-Techne | Catalog # 2782

Key Product Details

Biological Activity for TCS 46b

Technical Data for TCS 46b

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TCS 46b

Product Documents for TCS 46b

COA

Certificate of Analysis

SDS

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