TAT-PDHPS1
Tocris Bioscience, part of Bio-Techne | Catalog # 7832
YAP inhibitor
Product Description
TAT-PDHPS1 is a YAP inhibitor (Yes-associated protein inhibitor). It comprises the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), which activates protein phosphatase 2A (PP2A). This activation leads to the phosphorylation of YAP and the suppression of YAP-targeted genes. TAT-PDHPS1 inhibits the proliferation of ovarian cancer cells in vitro and ovarian tumor growth in a subcutaneous xenograft mouse model.Product Specifications
Molecular Weight
3744.32
Formula
C156H280N62O45
Storage
Store at -20°C
Purity
≥95% (HPLC)
InChI Key
NNCYONQIMWXOHL-MRKNDOTPSA-N
SMILES
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 2mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Pan Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling. Mol.Cancer Ther. 2022 PMID: 35545004
Product Specific Notices for TAT-PDHPS1
For research use only
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