Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.

Product Specifications

Molecular Weight

405.41

Formula

C₁₇H₂₃N₇O₅

Storage

Store at -20°C

Purity

≥96% (HPLC)

Chemical Name

N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide

CAS Number

103300-74-9

PubChem ID

114750

InChI Key

LQZAIAZUDWIVPM-SRVKXCTJSA-N

SMILES

CN(C(C[C@@H]([C@@](N[C@@H](CC3=CNC=N3)C(N2[C@H]([C@](N)=O)CCC2)=O)=O)N1)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	20.27	50

Preparing Stock Solutions for Taltirelin

The following data is based on the product molecular weight 405.41

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.93 mL	24.67 mL	49.33 mL
2.5 mM	0.99 mL	4.93 mL	9.87 mL
5 mM	0.49 mL	2.47 mL	4.93 mL
25 mM	0.10 mL	0.49 mL	0.99 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Urayama Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sci. 2002 PMID: 12467901
Tanabe The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems. Br.J.Pharmacol. 2007 PMID: 17220907
Suzuki Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety. J.Med.Chem. 1990 PMID: 2115588

Taltirelin

Tocris Bioscience, part of Bio-Techne | Catalog # 2672

Key Product Details

Description

Alternative Names

View all Thyrotropin-Releasing Hormone Receptor Agonists »

Product Description