SP 10

Name: SP 10
Brand: Tocris Bioscience
SKU: 7322

Tocris Bioscience, part of Bio-Techne | Catalog # 7322

Citations (1)

COA / SDS

Highly potent inhibitor of SARS-CoV Spike (S) protein and ACE2 interaction

Key Product Details

Description:	Highly potent inhibitor of SARS-CoV Spike (S) protein and ACE2 interaction
Purity:	≥95% (HPLC)
Molecular Weight:	1315.5

View Full Technical Details for SP 10

Technical Data
Citations

Biological Activity for SP 10

SP 10 is a peptide originally derived from SARS-CoV Spike (S) protein; corresponds to amino acid residues 668 to 679. Highly potent inhibitor of SARS-CoV S protein and ACE2 interaction (IC₅₀ = 1.88 nM in biochemical assay). Inhibits interaction of SARS-CoV S protein and Vero E6 cells in vitro.

Please note, this peptide displays 80% sequence identity to homologous site on SARS-CoV-2 S-protein (residues 689-697).

Technical Data for SP 10

M. Wt	1315.5
Formula	C₅₆H₉₄N₁₄O₂₀S
Single Letter Sequence	STSQKSIVAYTM
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	882157-88-2
PubChem ID	11693850
InChi Key	RBLTWUZIFRZOSV-SQWMWQRLSA-N
Smiles	O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SP 10

Solubility

Soluble to 1mg/ml in water

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References for SP 10

References are publications that support the biological activity of the product.

Ho Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2006 PMID: 16337697