SM 102

Name: SM 102
Brand: Tocris Bioscience
SKU: 8909

Tocris Bioscience, part of Bio-Techne | Catalog # 8909

COA / SDS

Cationic ionizable lipid

Key Product Details

Description:	Cationic ionizable lipid
Chemical Name:	1-Octylnonyl 8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]octanoate
Purity:	≥95% (HPLC)
Molecular Weight:	710.17

View Full Technical Details for SM 102

Technical Data
Citations

Biological Activity for SM 102

SM 102 is an ionizable cationic lipid (pKa = 6.68) used in the formulation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. Administration of LNPs containing SM 102 induces hepatic luciferase expression in mice. SM 102 is commonly formulated with cholesterol (Cat. No. 7945), DSPC (Cat. No. 7943), and DMG-PEG 2000 (Cat. No. 7944).

This product is supplied pre-dissolved in anhydrous ethanol, 100mg/mL

For more information on LNPs and available components see our Lipid Nanoparticles page.

Technical Data for SM 102

M. Wt	710.17
Formula	C₄₄H₈₇NO₅
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2089251-47-6
PubChem ID	126697616
InChi Key	BGNVBNJYBVCBJH-UHFFFAOYSA-N
Smiles	O=C(OCCCCCCCCCCC)CCCCCN(CCO)CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SM 102

Solubility

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 100mg/mL)

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References for SM 102

References are publications that support the biological activity of the product.

Sabnis A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human primates. Mol.Ther. 2018 PMID: 29653760
Hassett Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines. Mol Ther Nucleic Acids 2019 PMID: 30785039