DSPC

Name: DSPC
Brand: Tocris Bioscience
SKU: 7943

Tocris Bioscience, part of Bio-Techne | Catalog # 7943

Citations (18)

COA / SDS

Neutral phospholipid; component of lipid nanoparticles (LNPs)

Key Product Details

Description:	Neutral phospholipid; component of lipid nanoparticles (LNPs)
Alternative Names:	1,2-DSPC
Chemical Name:	1,2-Distearoyl-sn-glycero-3-phosphocholine
Purity:	≥95% (HPLC)
Molecular Weight:	790.15

View Full Technical Details for DSPC

Technical Data
Citations

Biological Activity for DSPC

DSPC is a phosphatidylcholine, a type of neutral phospholipid with two saturated long-chains (18:0). Commonly used in the generation of micelles, liposomes, lipid nanoparticles (LNPs) and other types of artificial membranes. DSPC is used in formulation of LNPs for nonviral drug delivery systems.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

For a fully formulate LNP containing DLin-MC3-DMA and a luciferase mRNA reporter, see MC3 LNP Luciferase (Cat. No. 8889).

Technical Data for DSPC

M. Wt	790.15
Formula	C₄₄H₈₈NO₈P
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	816-94-4
PubChem ID	94190
InChi Key	NRJAVPSFFCBXDT-HUESYALOSA-N
Smiles	[C@H](OC(CCCCCCCCCCCCCCCCC)=O)(COP(OCC[N+](C)(C)C)(=O)[O-])COC(CCCCCCCCCCCCCCCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DSPC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	chloroform	79.01	100
	ethanol	15.8	20 with gentle warming

Preparing Stock Solutions for DSPC

The following data is based on the product molecular weight 790.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.27 mL	6.33 mL	12.66 mL
5 mM	0.25 mL	1.27 mL	2.53 mL
10 mM	0.13 mL	0.63 mL	1.27 mL
50 mM	0.03 mL	0.13 mL	0.25 mL

Molarity Calculator

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Reconstitution Calculator

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References for DSPC

References are publications that support the biological activity of the product.

Zhang Liver-targeted siRNA lipid nanoparticles treat hepatic cirrhosis by dual antifibrotic and anti-inflammatory activities. ACS Nano 2020 PMID: 32378877
Lou Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J.Control Release 2020 PMID: 32619745