SKI II

Tocris Bioscience, part of Bio-Techne | Catalog # 2097

Selective non-lipid inhibitor of sphingosine kinase
Discontinued Product
2097 has been discontinued. View all Sphingosine Kinase Inhibitors products.

Key Product Details

Description

Selective non-lipid inhibitor of sphingosine kinase

View all Sphingosine Kinase Inhibitors »

Product Description

SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).

Product Specifications

Molecular Weight

302.78

Formula

C15H11ClN2OS

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

CAS Number

312636-16-1

PubChem ID

753704

InChI Key

ZFGXZJKLOFCECI-UHFFFAOYSA-N

SMILES

OC1=CC=C(NC2=NC(=CS2)C2=CC=C(Cl)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.28 100

Preparing Stock Solutions for SKI II

The following data is based on the product molecular weight 302.78

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.30 mL 16.51 mL 33.03 mL
5 mM 0.66 mL 3.30 mL 6.61 mL
10 mM 0.33 mL 1.65 mL 3.30 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SKI II

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SKI II

For research use only

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