SJPYT 310
Tocris Bioscience, part of Bio-Techne | Catalog # 8839
Potent and selective PXR antagonist
Key Product Details
Description
Potent and selective PXR antagonist
Product Description
SJPYT 310 is a potent and selective PXR antagonist (IC50 values are 4 and 9 nM for binding and cellular activity, respectively). SJPYT 310 displays selectivity for hPXR without affecting the activity of mPXR, hCAR, hFXR, hLXRα, or hVDR. SJPYT 310 and SJPYT 328 (Cat. No. 8840) can be used as benchmark compounds for referencing "full agonist" and "full antagonist" when screening for new drugs in cellular models. SJPYT 328 shows no toxicity.SJPYT 310 shows no toxicity.Licensing Information
Sold under license from St. Jude Children's Research HospitalProduct Specifications
Molecular Weight
464.61
Formula
C27H36N4O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[5-(1,1-Dimethylethyl)-2-[(1S)-1-methylbutoxy]phenyl]-1-(2-methoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide
CAS Number
2883814-84-2
PubChem ID
171352643
InChI Key
UOXKTTLWMUQDFC-SFHVURJKSA-N
SMILES
CC1=C(C(NC2=C(C=CC(C(C)(C)C)=C2)O[C@@H](C)CCC)=O)N=NN1C3=C(C=CC(C)=C3)OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.46 | 100 | |
| Ethanol | 46.46 | 100 |
Preparing Stock Solutions
for SJPYT 310
The following data is based on the product molecular weight 464.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.76 mL | 21.52 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.30 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Design and optimization of 1 H-1,2,3-Triazole-4-carboxamides as novel, potent, and selective inverse agonists and antagonists of PXR. J.Med.Chem. 2022 PMID: 36480704
- Garcia-Maldonado Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat.Commun. 2024 PMID: 38744881
Product Specific Notices for SJPYT 310
For research use only
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