SIB 1893

Name: SIB 1893
Brand: Tocris Bioscience
SKU: 1214

Tocris Bioscience, part of Bio-Techne | Catalog # 1214

Citations (16)

COA / SDS

mGlu5 antagonist; also positive allosteric modulator at mGlu4 receptors

Discontinued Product

1214 has been discontinued. View all Group I mGluR Antagonists products.

Key Product Details

Description:	mGlu₅ antagonist; also positive allosteric modulator at mGlu₄ receptors
Chemical Name:	2-Methyl-6-(2-phenylethenyl)pyridine
Molecular Weight:	195.26

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Technical Data
Citations

Biological Activity for SIB 1893

SIB 1893 is an a highly selective non-competitive antagonist for the metabotropic glutamate mGlu₅ receptor subtype; displays an IC₅₀ value of 0.3 μM at hmGlu₅, compared with > 100 μM at hmGlu_1b, hmGlu₂, hmGlu₆, hmGlu₇ and hmGlu₈. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu₄ receptors.

Technical Data for SIB 1893

M. Wt	195.26
Formula	C₁₄H₁₃N
Storage	Desiccate at +4°C
CAS Number	6266-99-5
PubChem ID	4713
InChi Key	QFWCYNPOPKQOKV-UHFFFAOYSA-N
Smiles	CC1=NC(\C=C\C2=CC=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SIB 1893

References are publications that support the biological activity of the product.

Mathiesen Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br.J.Pharmacol. 2003 PMID: 12684257
Varney SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J.Pharmacol.Exp.Ther. 1999 PMID: 10381773
Chapman Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology 2000 PMID: 10854901

SIB 1893

Tocris Bioscience, part of Bio-Techne | Catalog # 1214

Key Product Details

Biological Activity for SIB 1893

Technical Data for SIB 1893

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References for SIB 1893

Product Documents for SIB 1893

COA

Certificate of Analysis

SDS

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