SIB 1508Y maleate

Tocris Bioscience, part of Bio-Techne | Catalog # 4766

Potent agonist of α4β2, α2β4, α4β4 and α3β4 nACh receptors
Discontinued Product
4766 has been discontinued. View all Additional Nicotinic Receptor Agonists products.

Key Product Details

Description

Potent agonist of α4β2, α2β4, α4β4 and α3β4 nACh receptors

View all Additional Nicotinic Receptor Agonists »

Product Description

SIB 1508Y maleate is a potent neuronal nicotinic ACh receptor agonist (EC50 values are 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo.

Product Specifications

Molecular Weight

302.33

Formula

C12H14N2.C4H4O4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

3-Ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]pyridine maleate salt

CAS Number

192231-16-6

PubChem ID

10968648

InChI Key

BCPPKHPWLRPWBJ-OURKGEEVSA-N

SMILES

CN1CCC[C@H]1[C@]2=CC(C#C)=CN=C2.O=C(\C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.23 100
DMSO 15.12 50

Preparing Stock Solutions for SIB 1508Y maleate

The following data is based on the product molecular weight 302.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.54 mL 33.08 mL
5 mM 0.66 mL 3.31 mL 6.62 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SIB 1508Y maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SIB 1508Y maleate

For research use only

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