SGC CK2-1
Tocris Bioscience, part of Bio-Techne | Catalog # 7450
Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2
Key Product Details
Description
Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2
Product Description
SGC CK2-1 is a potent inhibitor of casein kinase 2 (CK2) with activity at both the CK2A2 and CK2A1 isoforms (IC50 values are 2.3-16 nM and 4.2-36 nM respectively). SGC CK-1 also inhibits DYRK2 (IC50 = 440 nM).Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC CK2-1 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC CK2-1 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
375.44
Formula
C20H21N7O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[5-[[3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide
CAS Number
2470424-39-4
PubChem ID
146681133
InChI Key
YKDZIFFKQUNVHH-UHFFFAOYSA-N
SMILES
CCC(NC1=C(C=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=C1)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.54 | 100 |
Preparing Stock Solutions
for SGC CK2-1
The following data is based on the product molecular weight 375.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.66 mL | 13.32 mL | 26.64 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.33 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wells Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem.Biol. 2021 PMID: 33484635
Product Specific Notices for SGC CK2-1
For research use only
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