SGC-CBP30

Name: SGC-CBP30
Brand: Tocris Bioscience
SKU: 4889
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4889

(1)

Citations (14)

COA / SDS

Potent CBP/p300 BRD inhibitor

Key Product Details

Description:	Potent CBP/p300 BRD inhibitor
Chemical Name:	2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole
Purity:	≥98% (HPLC)
Molecular Weight:	509.04

View Full Technical Details for SGC-CBP30

Technical Data
Citations / Reviews (1)

Biological Activity for SGC-CBP30

SGC-CBP30 is a potent CBP/p300 bromodomain (BRD) inhibitor (K_d values are 21 and 32 nM for CBP and p300 BRDs respectively). Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. Accelerates FRAP recovery in cells at a concentration of 1 μM. SGC-CBP30 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-CBP30 probe summary on the SGC website.

Compound Libraries for SGC-CBP30

SGC-CBP30 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC-CBP30 is reviewed on the chemical probes website.

Technical Data for SGC-CBP30

M. Wt	509.04
Formula	C₂₈H₃₃ClN₄O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1613695-14-9
PubChem ID	72201027
InChi Key	GEPYBHCJBORHCE-SFHVURJKSA-N
Smiles	CC1=C(C(C)=NO1)C2=CC=C3C(N=C(CCC4=CC(Cl)=C(OC)C=C4)N3C[C@@H](N5CCOCC5)C)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC-CBP30

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	100

Preparing Stock Solutions for SGC-CBP30

The following data is based on the product molecular weight 509.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.96 mL	9.82 mL	19.64 mL
5 mM	0.39 mL	1.96 mL	3.93 mL
10 mM	0.20 mL	0.98 mL	1.96 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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Reconstitution Calculator

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References for SGC-CBP30

References are publications that support the biological activity of the product.

Guan Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 2022 PMID: 35418683
Hay Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. J.Am.Chem.Soc. 2014 PMID: 24946055
Hammitzsch CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. Proc.Natl.Acad.Sci.U.S.A. 2015 PMID: 26261308
Gallenkamp Bromodomains and their pharmacological inhibitors. ChemMedChem 2014 PMID: 24497428