SGC AAK1 1N

Name: SGC AAK1 1N
Brand: Tocris Bioscience
SKU: 6529

Tocris Bioscience, part of Bio-Techne | Catalog # 6529

COA / SDS

Negative control for SGC AAK1 1 (Cat.No. 6528)

Key Product Details

Description:	Negative control for SGC AAK1 1 (Cat.No. 6528)
Chemical Name:	N-[6-[3-[(Cyclopropylsulfonyl)amino]phenyl]-1H-indazol-3-yl]-2-methylpropanamide
Purity:	≥97% (HPLC)
Molecular Weight:	398.48

View Full Technical Details for SGC AAK1 1N

Technical Data
Citations

Biological Activity for SGC AAK1 1N

SGC AAK1 1N is a negative control for SGC AAK1 1 (Cat. No. 6528).

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-AAK1-1 probe summary on the SGC website.

Technical Data for SGC AAK1 1N

M. Wt	398.48
Formula	C₂₀H₂₂N₄O₃S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	2242913-80-8
PubChem ID	146121078
InChi Key	RAIAORGFMNXPOV-UHFFFAOYSA-N
Smiles	O=C(C(C)C)NC1=NNC2=C1C=CC(C3=CC=CC(NS(=O)(C4CC4)=O)=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC AAK1 1N

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.85	100
	ethanol	3.98	10

Preparing Stock Solutions for SGC AAK1 1N

The following data is based on the product molecular weight 398.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.55 mL	25.10 mL
5 mM	0.50 mL	2.51 mL	5.02 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Molarity Calculator

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Reconstitution Calculator

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References for SGC AAK1 1N

References are publications that support the biological activity of the product.

Agajanian WNT activates the AAK1 kinase to promote clathrin-mediated endocytosis of LRP6 and establish a negative feedback loop. Cell Rep. 2019 PMID: 30605688