SGC AAK1 1

Name: SGC AAK1 1
Brand: Tocris Bioscience
SKU: 6528

Tocris Bioscience, part of Bio-Techne | Catalog # 6528

Citations (4)

COA / SDS

AAK1 and BMP2K inhibitor; activates Wnt signaling

Key Product Details

Description:	AAK1 and BMP2K inhibitor; activates Wnt signaling
Chemical Name:	N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	427.52

View Full Technical Details for SGC AAK1 1

Technical Data
Citations

Biological Activity for SGC AAK1 1

SGC AAK1 1 is an adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor (IC₅₀ values are 233 nM and 1.48 μM for AAK1 and BMP2K, respectively). Inhibits AAK1-dependent phosphorylation of AP2M1. Activates Wnt signaling.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-AAK1-1 probe summary on the SGC website.

Compound Libraries for SGC AAK1 1

SGC AAK1 1 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for SGC AAK1 1

M. Wt	427.52
Formula	C₂₁H₂₅N₅O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2247894-32-0
PubChem ID	134812845
InChi Key	UCBIQZUJJSVQHL-UHFFFAOYSA-N
Smiles	O=C(NC1=NNC2=C1C=CC(C3=CC=CC(NS(=O)(N(CC)CC)=O)=C3)=C2)C4CC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC AAK1 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.75	100

Preparing Stock Solutions for SGC AAK1 1

The following data is based on the product molecular weight 427.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.70 mL	23.39 mL
5 mM	0.47 mL	2.34 mL	4.68 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for SGC AAK1 1

References are publications that support the biological activity of the product.

Agajanian WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019 PMID: 30605688