SEN 12333

Tocris Bioscience, part of Bio-Techne | Catalog # 4441

α7 nAChR agonist; also histamine H3 antagonist
Discontinued Product
4441 has been discontinued. View all Nicotinic (a7) Receptor Agonists products.

Key Product Details

Description

α7 nAChR agonist; also histamine H3 antagonist

Alternative Names

WAY 317538

View all Nicotinic (a7) Receptor Agonists »

Product Description

SEN 12333 is a α7 nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs). Also displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. Brain penetrant and orally bioavailable.

Product Specifications

Molecular Weight

339.43

Formula

C20H25N3O2

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide

CAS Number

874450-44-9

PubChem ID

45484303

InChI Key

XCHIZTUBUXZESJ-UHFFFAOYSA-N

SMILES

O=C(CCCCN3CCOCC3)NC(C=C2)=CC=C2C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.94 100

Preparing Stock Solutions for SEN 12333

The following data is based on the product molecular weight 339.43

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.46 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SEN 12333

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SEN 12333

For research use only

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