SB 268262

Name: SB 268262
Brand: Tocris Bioscience
SKU: 4314

Tocris Bioscience, part of Bio-Techne | Catalog # 4314

Citations (2)

COA / SDS

Selective non-peptide CGRP antagonist

Discontinued Product

4314 has been discontinued. View all Calcitonin and Related Receptor Antagonists products.

Key Product Details

Description:	Selective non-peptide CGRP antagonist
Chemical Name:	N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	401.46

View Full Technical Details for SB 268262

Technical Data
Citations

Biological Activity for SB 268262

SB 268262 is a selective non-peptide CGRP₁ antagonist. Inhibits [¹²⁵I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC₅₀ values are 0.24 and 0.83 nM respectively).

Licensing Information

Sold with the permission of GlaxoSmithKline.

Technical Data for SB 268262

M. Wt	401.46
Formula	C₁₈H₁₅N₃O₄S₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	217438-17-0
PubChem ID	6918567
InChi Key	YXHLPJQQPOMPGE-UHFFFAOYSA-N
Smiles	O=S(C2=NC=CS2)C1=CC=C(C(N(C)C3=CC=CC=C3C)=O)C=C1[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SB 268262

References are publications that support the biological activity of the product.

Aiyar Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J.Pharmacol.Exp.Ther. 2001 PMID: 11181905