SB 204990

Tocris Bioscience, part of Bio-Techne | Catalog # 4962

ATP citrate lyase (ACLY) inhibitor
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Key Product Details

Description

ATP citrate lyase (ACLY) inhibitor

View all ATP Citrate Lyase Inhibitors »

Product Description

SB 204990 is an ATP citrate lyase (ACLY) inhibitor; it is a prodrug of SB 201076. SB 204990 inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells. Suppresses growth of cancer cells showing aerobic glycolysis in vitro and in vivo. Orally active.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications

Molecular Weight

389.27

Formula

C18H22Cl2O5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

CAS Number

154566-12-8

PubChem ID

10340264

InChI Key

YTRNLFYTHYWDAU-KDOFPFPSSA-N

SMILES

ClC(C=C(Cl)C=C2)=C2CCCCCC[C@@H](OC1=O)C[C@]1(O)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.93 100
Ethanol 38.93 100

Preparing Stock Solutions for SB 204990

The following data is based on the product molecular weight 389.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.69 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Reconstitution Calculator

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Product Documents for SB 204990

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 204990

For research use only

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