ATP Citrate Lyase Inhibitors Products

ATP citrate lyase (ATP citrate synthase, ACLY), EC 2.3.3.8, is a transferase that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate. ACLY has been shown to be the key regulator between the high rates of aerobic glycolysis and de novo lipid synthesis, exhibited in many types of proliferating tumor cells.

ACLY is a homotetramer that is activated by hormones and growth factors involved in glucose uptake and metabolism, as well as anabolic growth. Insulin has ...