(S)-(-)-5-Iodowillardiine
Tocris Bioscience, part of Bio-Techne | Catalog # 0307
Highly potent and subtype-selective kainate agonist
Key Product Details
Description
Highly potent and subtype-selective kainate agonist
Product Description
Demonstrates high affinity for the kainate receptor subtype hGluK1 (formerly hGluR5) (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluK2 (formerly hGluR6).Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Product Specifications
Molecular Weight
325.06
Formula
C7H8IN3O4
Storage
Store at RT
Purity
≥98% (HPLC)
CAS Number
140187-25-3
PubChem ID
447196
InChI Key
AXXYLTBQIQBTES-BYPYZUCNSA-N
SMILES
O=C(N1)N(C[C@]([H])(N)C(O)=O)C=C(I)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 8.12 | 25 |
Preparing Stock Solutions
for (S)-(-)-5-Iodowillardiine
The following data is based on the product molecular weight 325.06
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 12.31 mL | 61.53 mL | 123.05 mL |
| 1.25 mM | 2.46 mL | 12.31 mL | 24.61 mL |
| 2.5 mM | 1.23 mL | 6.15 mL | 12.31 mL |
| 12.5 mM | 0.25 mL | 1.23 mL | 2.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Thompson Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots. Br.J.Pharmacol.
- Wong Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones. J.Neurosci. 1994 PMID: 7515954
- Patneau Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 1992 PMID: 1371315
- Swanson Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Mol.Pharmacol. 1998 PMID: 9584222
- Jane Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 1997 PMID: 9357531
Product Specific Notices for (S)-(-)-5-Iodowillardiine
For research use only
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