RSVA 405

Tocris Bioscience, part of Bio-Techne | Catalog # 5138

AMPK activator; also STAT3 inhibitor
Discontinued Product
5138 has been discontinued. View all AMPK Activators products.

Key Product Details

Description

AMPK activator; also STAT3 inhibitor

View all AMPK Activators »

Product Description

RSVA 405 is an AMP-activated protein kinase (AMPK) activator (EC50 = 1 μM); activates AMPK indirectly through a CaMKKβ-dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC50 = 0.5 μM). Induces autophagy and promotes Aβ degradation in vitro. Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice.

Product Specifications

Molecular Weight

312.37

Formula

C17H20N4O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid

CAS Number

140405-36-3

PubChem ID

9613337

InChI Key

GWQPCBPAOAFXSJ-XDHOZWIPSA-N

SMILES

O=C(N/N=C/C2=C(O)C=C(N(CC)CC)C=C2)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.62 50
Ethanol 1.56 5

Preparing Stock Solutions for RSVA 405

The following data is based on the product molecular weight 312.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.40 mL 32.01 mL 64.03 mL
2.5 mM 1.28 mL 6.40 mL 12.81 mL
5 mM 0.64 mL 3.20 mL 6.40 mL
25 mM 0.13 mL 0.64 mL 1.28 mL

Calculators

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Product Documents for RSVA 405

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RSVA 405

For research use only

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