Rp-8-pCPT-cGMPS sodium
Tocris Bioscience, part of Bio-Techne | Catalog # 5524
PKG inhibitor
Discontinued Product
5524 has been discontinued.
View all Protein Kinase G Inhibitors products.
Product Description
Rp-8-pCPT-cGMPS sodium is a PKG inhibitor (Ki values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.Product Specifications
Molecular Weight
525.86
Formula
C16H14ClN5NaO6PS2
Storage
Store at -20°C
Purity
≥99% (HPLC)
Chemical Name
8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium
CAS Number
208445-07-2
PubChem ID
91826097
InChI Key
JERAACMSJYSCBY-OZOPYAHTSA-M
SMILES
O=C1N=C(N)NC2=C1N=C(SC4=CC=C(Cl)C=C4)N2[C@@H]3O[C@@](CO[P@](O5)(S[Na])=O)([H])[C@]5([H])[C@H]3O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 52.59 | 100 | |
| DMSO | 52.59 | 100 |
Preparing Stock Solutions
for Rp-8-pCPT-cGMPS sodium
The following data is based on the product molecular weight 525.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.90 mL | 9.51 mL | 19.02 mL |
| 5 mM | 0.38 mL | 1.90 mL | 3.80 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.90 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Poppe Cyclic nucleotide analogs as probes of signaling pathways. Nat.Methods 2008 PMID: 18376388
- Gamm The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J.Biol.Chem. 1995 PMID: 7593002
- Kim Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proc.Natl.Acad.Sci.U.S.A. 2015 PMID: 25713349
Product Specific Notices for Rp-8-pCPT-cGMPS sodium
For research use only
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