Rottlerin

Tocris Bioscience, part of Bio-Techne | Catalog # 1610

Reported PKCδ inhibitor
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Key Product Details

Description

Reported PKCδ inhibitor

View all Protein Kinase C Inhibitors »

Product Description

Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.

Product Specifications

Molecular Weight

516.55

Formula

C30H28O8

Storage

Store at +4°C

Purity

≥95% (HPLC)

Chemical Name

3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone

CAS Number

82-08-6

PubChem ID

5281847

InChI Key

DEZFNHCVIZBHBI-ZHACJKMWSA-N

SMILES

CC(=O)C1=C(O)C(CC2=C(O)C(C(=O)\C=C\C3=CC=CC=C3)=C3OC(C)(C)C=CC3=C2O)=C(O)C(C)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.33 20

Preparing Stock Solutions for Rottlerin

The following data is based on the product molecular weight 516.55

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.68 mL 48.40 mL 96.80 mL
1 mM 1.94 mL 9.68 mL 19.36 mL
2 mM 0.97 mL 4.84 mL 9.68 mL
10 mM 0.19 mL 0.97 mL 1.94 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Rottlerin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Rottlerin

For research use only

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