RJR 2429 dihydrochloride

Name: RJR 2429 dihydrochloride
Brand: Tocris Bioscience
SKU: 1271

Tocris Bioscience, part of Bio-Techne | Catalog # 1271

COA / SDS

nAChR agonist; displays selectivity for α4β2, α1βγδ and α3β4 subtypes

Discontinued Product

1271 has been discontinued. View all Additional Nicotinic Receptor Agonists products.

Key Product Details

Description:	nAChR agonist; displays selectivity for α4β2, α1βγδ and α3β4 subtypes
Chemical Name:	(±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	261.19

View Full Technical Details for RJR 2429 dihydrochloride

Technical Data
Citations

Biological Activity for RJR 2429 dihydrochloride

RJR 2429 dihydrochloride is a potent nAChR agonist that displays selectivity for α4β2 (K_i = 1 nM) and α1βγδ subtypes (EC₅₀ values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC₅₀ = 2 nM) and inhibits ion flux in thalamic neurons (IC₅₀ = 154 nM). Also putative α3β4 agonist that potentiates catecholamine release.

Technical Data for RJR 2429 dihydrochloride

M. Wt	261.19
Formula	C₁₂H₁₆N₂.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1021418-53-0
PubChem ID	56972204
InChi Key	PIUNXHHZRIUBOV-UHFFFAOYSA-N
Smiles	C1(C2N3CCC(CC3)C2)=CC=CN=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for RJR 2429 dihydrochloride

References are publications that support the biological activity of the product.

Bhatti Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands. J.Org.Chem. 2008 PMID: 18363376
Yokotani Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from isolated rat adrenal gland. Eur.J.Pharmacol. 2002 PMID: 12098588
Bencherif The heterocyclic substituted pyridine derivative (±)-2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 1998 PMID: 9495846

RJR 2429 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1271

Key Product Details

Biological Activity for RJR 2429 dihydrochloride

Technical Data for RJR 2429 dihydrochloride

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Dilution Calculator

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References for RJR 2429 dihydrochloride

Product Documents for RJR 2429 dihydrochloride

COA

Certificate of Analysis

SDS

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