RIPK2 inhibitor 1
Tocris Bioscience, part of Bio-Techne | Catalog # 6603
Potent RIPK2 inhibitor
Product Description
RIPK2 inhibitor 1 is a potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 of 5-10 nM). It inhibits NF-κB activity and decreases cancer cell proliferation by 70%. In vivo, RIPK2 inhibitor 1 inhibits intestinal and lung inflammation with low toxicity in rodent models.Product Specifications
Molecular Weight
410.48
Formula
C25H22N4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-(Benzoylamino)-4-methyl-N-[3-(1-methyl-1H-imidazol-2-yl)phenyl]benzamide
CAS Number
1290490-78-6
PubChem ID
99506096
InChI Key
OIIYBZHRYXJCHR-UHFFFAOYSA-N
SMILES
CN1C=CN=C1C2=CC(NC(C3=CC(NC(C4=CC=CC=C4)=O)=C(C)C=C3)=O)=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.05 | 100 |
Preparing Stock Solutions
for RIPK2 inhibitor 1
The following data is based on the product molecular weight 410.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.18 mL | 24.36 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Salla Identification and characterization of novel receptor-interacting serine/threonine-protein kinase 2 inhibitors using structural similarity analysis. J.Pharmacol.Exp.Ther. 2018 PMID: 29555876
Product Specific Notices for RIPK2 inhibitor 1
For research use only
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