RFRP 3 (human)

Name: RFRP 3 (human)
Brand: Tocris Bioscience
SKU: 4683

Tocris Bioscience, part of Bio-Techne | Catalog # 4683

Citations (1)

COA / SDS

NPFF1 agonist; GnIH homolog

Discontinued Product

4683 has been discontinued. View all Neuropeptide FF/AF Receptor Agonists products.

Key Product Details

Description:	NPFF₁ agonist; GnIH homolog
Alternative Names:	Neuropeptide NPVF
Purity:	≥95% (HPLC)
Molecular Weight:	969.15

View Full Technical Details for RFRP 3 (human)

Technical Data
Citations

Biological Activity for RFRP 3 (human)

RFRP 3 (human) is an agonist of the NPFF₁ receptor (IC₅₀ = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.

Technical Data for RFRP 3 (human)

M. Wt	969.15
Formula	C₄₅H₇₂N₁₄O₁₀
Single Letter Sequence	VPNLPQRF (Phe-8 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	311309-27-0
PubChem ID	71451611
InChi Key	JFZCLMZUABKABL-GVCDGELBSA-N
Smiles	[H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for RFRP 3 (human)

References are publications that support the biological activity of the product.

Ubuka Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One 2009 PMID: 20027225
Hinuma New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell Biol. 2000 PMID: 11025660
Rizwan RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 2012 PMID: 22691552

RFRP 3 (human)

Tocris Bioscience, part of Bio-Techne | Catalog # 4683

Key Product Details

Biological Activity for RFRP 3 (human)

Technical Data for RFRP 3 (human)

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for RFRP 3 (human)

Product Documents for RFRP 3 (human)

COA

Certificate of Analysis

SDS

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