RAGE antagonist peptide
Tocris Bioscience, part of Bio-Techne | Catalog # 6259
RAGE antagonist
Discontinued Product
6259 has been discontinued.
View all NFkB/IkB Inhibitors products.
Product Description
RAGE antagonist peptide is a receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-κB activity in human PDAC cell lines. Inhibits effects of TDI exposure in BALB/c mice.Product Specifications
Molecular Weight
1272.56
Formula
C57H101N13O17S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
1092460-91-7
PubChem ID
127021052
InChI Key
UPCWJIBXKJZZLN-YZLORNOTNA-N
SMILES
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
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Background References
References are publications that support the biological activity of the product.
- Yao The receptor for advanced glycation end products is required for beta-catenin stabilization in a chemical-induced asthma model. Br.J.Pharmacol. 2016 PMID: 27332707
- Arumugam S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin.Cancer.Res. 2012 PMID: 22718861
Product Specific Notices for RAGE antagonist peptide
For research use only
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