RA 2
Tocris Bioscience, part of Bio-Techne | Catalog # 7129
Potent negative modulator of KCa2.3 and KCa3.1 channels
Key Product Details
Description
Potent negative modulator of KCa2.3 and KCa3.1 channels
Product Description
RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays >55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.Product Specifications
Molecular Weight
414.36
Formula
C22H16F2O6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate)
CAS Number
1867107-62-7
InChI Key
XOZKRECPKXTNAK-UHFFFAOYSA-N
SMILES
OC1=C(C=C(C(OCC2=CC(COC(C3=CC(F)=C(C=C3)O)=O)=CC=C2)=O)C=C1)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.44 | 100 | |
| Ethanol | 41.44 | 100 |
Preparing Stock Solutions
for RA 2
The following data is based on the product molecular weight 414.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.07 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Olivan-Viguera Vascular reactivity profile of novel KCa3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 2016 PMID: 26821335
- Olivan-Viguera A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol.Pharmacol. 2015 PMID: 25468883
Product Specific Notices for RA 2
For research use only
Loading...
Loading...