SKA 31

Name: SKA 31
Brand: Tocris Bioscience
SKU: 3670
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3670

(1)

Citations (14)

COA / SDS

KCa3.1 (IK) and KCa2 (SK) channel activator

Key Product Details

Description:	K_Ca3.1 (IK) and K_Ca2 (SK) channel activator
Chemical Name:	Naphtho[1,2-d]thiazol-2-ylamine
Purity:	≥99% (HPLC)
Molecular Weight:	200.26

View Full Technical Details for SKA 31

Technical Data
Citations / Reviews (1)

Biological Activity for SKA 31

SKA 31 is an activator of K_Ca3.1 and K_Ca2 channels (EC₅₀ values are 260, 2900, 2900 nM for K_Ca3.1, K_Ca2.1 and K_Ca2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

Compound Libraries for SKA 31

SKA 31 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SKA 31

M. Wt	200.26
Formula	C₁₁H₈N₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	40172-65-4
PubChem ID	94880
InChi Key	FECQXVPRUCCUIL-UHFFFAOYSA-N
Smiles	NC3=NC2=C(S3)C=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKA 31

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.03	100
	ethanol	20.03	100

Preparing Stock Solutions for SKA 31

The following data is based on the product molecular weight 200.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.99 mL	24.97 mL	49.94 mL
5 mM	1.00 mL	4.99 mL	9.99 mL
10 mM	0.50 mL	2.50 mL	4.99 mL
50 mM	0.10 mL	0.50 mL	1.00 mL

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Reconstitution Calculator

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References for SKA 31

References are publications that support the biological activity of the product.

Brahler Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 2009 PMID: 19380617
Sankaranarayanan Naphtho[1,2-d]thaizol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol.Pharmacol. 2009 PMID: 18955585