Proxyfan oxalate

Name: Proxyfan oxalate
Brand: Tocris Bioscience
SKU: 2477

Tocris Bioscience, part of Bio-Techne | Catalog # 2477

Citations (7)

COA / SDS

High affinity H3 ligand

Discontinued Product

2477 has been discontinued. View all Histamine H3 Receptor Agonists products.

Key Product Details

Description:	High affinity H₃ ligand
Chemical Name:	4-[3-(Phenylmethoxy)propyl]-1H-imidazole oxalate
Purity:	≥98% (HPLC)
Molecular Weight:	306.32

View Full Technical Details for Proxyfan oxalate

Technical Data
Citations

Biological Activity for Proxyfan oxalate

Proxyfan oxalate is a high affinity histamine H₃ receptor ligand (pK_i = 8.62) that acts as a protean agonist at recombinant and native receptors. In functional studies, activity ranges from full agonist to inverse agonist depending on system used. Displays partial agonist effects on cAMP inhibition and MAPK activity, neutral antagonist activity on histamine release and partial inverse agonism of [³H]-arachidonic acid release.

Technical Data for Proxyfan oxalate

M. Wt	306.32
Formula	C₁₃H₁₆N₂O.C₂H₂O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1620017-81-3
PubChem ID	76900838
InChi Key	QVMZCQMJBQSPSW-UHFFFAOYSA-N
Smiles	OC(=O)C(O)=O.C(COCC1=CC=CC=C1)CC1=CN=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Proxyfan oxalate

References are publications that support the biological activity of the product.

Krueger G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. J.Pharmacol.Exp.Ther 2005 PMID: 15821027
Gbahou Protean agonism at histamine H₃ receptors in vitro and in vivo. Proc.Natl.Acad.Sci.USA
Baldi The H₃ receptor protean agonist proxyfan enhances the expression of fear memory in the rat. Neuropharmacology 2005 PMID: 15695163

Proxyfan oxalate

Tocris Bioscience, part of Bio-Techne | Catalog # 2477

Key Product Details

Biological Activity for Proxyfan oxalate

Technical Data for Proxyfan oxalate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Proxyfan oxalate

Product Documents for Proxyfan oxalate

COA

Certificate of Analysis

SDS

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