Propranolol hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0624
Key Product Details
| Description: | β antagonist |
| Chemical Name: | (RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride |
| Molecular Weight: | 295.81 |
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Small molecules affect the rate of cardiomyocyte contraction. Cardiomyocytes were differentiated from the BG01V human embryonic stem cells and assessed for their ability to contract using the Fluo-4 calcium binding assay. Rate interval graph show fluctuations in Fluo-4 fluorescence intensity, indicative of cardiomyocyte contraction, under basal conditions (brown; untreated) and following sequential treatment with Isoproterenol (blue; Catalog # 1747), a beta -adrenergic agonist, and Propranolol (tan; Catalog # 0624), a beta -adrenergic antagonist. Table shows drug concentrations and contraction rate of cardiomyocytes during each treatment. The contraction rate of differentiated cardiomyocytes was determined as the number of contractions (contraction-interval plus relaxation interval) per minute. |