Prazosin hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 0623

α1 and α2B antagonist; also MT3 antagonist
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Key Product Details

Description

α1 and α2B antagonist; also MT3 antagonist

View all Adrenergic alpha-1 Receptor Antagonists »

Product Description

Prazosin hydrochloride is an α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). In prostate cancer cells, Prazosin induces DNA damage stress, Cdk1 inactivation, G2 checkpoint arrest and apoptosis. In mice bearing prostate cancer xenografts, oral administration of Prazosin reduces tumor mass.

Product Specifications

Molecular Weight

419.87

Formula

C19H21N5O4.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

CAS Number

19237-84-4

PubChem ID

68546

InChI Key

WFXFYZULCQKPIP-UHFFFAOYSA-N

SMILES

Cl.COC1=CC2=NC(=NC(N)=C2C=C1OC)N1CCN(CC1)C(=O)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25
Ethanol 5

Preparing Stock Solutions for Prazosin hydrochloride

The following data is based on the product molecular weight 419.87

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.53 mL 47.63 mL 95.27 mL
1.25 mM 1.91 mL 9.53 mL 19.05 mL
2.5 mM 0.95 mL 4.76 mL 9.53 mL
12.5 mM 0.19 mL 0.95 mL 1.91 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Prazosin hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Prazosin hydrochloride

For research use only

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