Prazosin hydrochloride

Name: Prazosin hydrochloride
Brand: Tocris Bioscience
SKU: 0623

Tocris Bioscience, part of Bio-Techne | Catalog # 0623

Citations (52)

COA / SDS

α1 and α2B antagonist; also MT3 antagonist

Key Product Details

Description:	α₁ and α_2B antagonist; also MT₃ antagonist
Chemical Name:	1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	419.87

View Full Technical Details for Prazosin hydrochloride

Technical Data
Citations

Biological Activity for Prazosin hydrochloride

Prazosin hydrochloride is an α₁ and α_2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT₃ receptor (K_i = 10.2 nM). In prostate cancer cells, Prazosin induces DNA damage stress, Cdk1 inactivation, G₂ checkpoint arrest and apoptosis. In mice bearing prostate cancer xenografts, oral administration of Prazosin reduces tumor mass.

Compound Libraries for Prazosin hydrochloride

Prazosin hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Prazosin hydrochloride

M. Wt	419.87
Formula	C₁₉H₂₁N₅O₄.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	19237-84-4
PubChem ID	68546
InChi Key	WFXFYZULCQKPIP-UHFFFAOYSA-N
Smiles	Cl.COC1=CC2=NC(=NC(N)=C2C=C1OC)N1CCN(CC1)C(=O)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Prazosin hydrochloride

	Solvent	Max Conc. mM
Solubility
	DMSO	25
	ethanol	5

Preparing Stock Solutions for Prazosin hydrochloride

The following data is based on the product molecular weight 419.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.53 mL	47.63 mL	95.27 mL
1.25 mM	1.91 mL	9.53 mL	19.05 mL
2.5 mM	0.95 mL	4.76 mL	9.53 mL
12.5 mM	0.19 mL	0.95 mL	1.91 mL

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References for Prazosin hydrochloride

References are publications that support the biological activity of the product.

Lin Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle. Neoplasia 2007 PMID: 17971903
Paul Characterisation of 2-[¹²⁵I]iodomelatonin binding sites in syrian hamster peripheral organs. J.Pharmacol.Exp.Ther. 1999 PMID: 10381796
Pickering and Niles Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus. Eur.J.Pharmacol. 1990 PMID: 2157597
Mathe Prazosin inhibits MK-801-induced hyperlocomotion and DA release in the nucleus accumbens. Eur.J.Pharmacol. 1996 PMID: 8864686