PPY A

Name: PPY A
Brand: Tocris Bioscience
SKU: 4730

Tocris Bioscience, part of Bio-Techne | Catalog # 4730

Citations (5)

COA / SDS

Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

Key Product Details

Description:	Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
Chemical Name:	5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	372.42

View Full Technical Details for PPY A

Technical Data
Citations

Biological Activity for PPY A

PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases (IC₅₀ values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.

Compound Libraries for PPY A

PPY A is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PPY A

M. Wt	372.42
Formula	C₂₂H₂₀N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	875634-01-8
PubChem ID	16750094
InChi Key	GYQRHHQPEMOLKH-UHFFFAOYSA-N
Smiles	O=C(N(C)C)C1=CN=CC(C2=CN=C(NC=C3C4=C(OC)C=CC=C4)C3=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PPY A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.24	100

Preparing Stock Solutions for PPY A

The following data is based on the product molecular weight 372.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.43 mL	26.85 mL
5 mM	0.54 mL	2.69 mL	5.37 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for PPY A

References are publications that support the biological activity of the product.

Noronha Inhibitors of ABL and the ABL-T315I mutation. Curr.Top.Med.Chem. 2008 PMID: 18673174
Zhou Crystal structure of the T315I mutant of AbI kinase. Chem.Biol.Drug.Des. 2007 PMID: 17718712