PNU 177864 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3355
Highly selective D3 antagonist
Discontinued Product
3355 has been discontinued.
View all Dopamine D3 Receptor Antagonists products.
Key Product Details
Description
Highly selective D3 antagonist
Product Description
PNU 177864 hydrochloride is a highly selective dopamine D3 receptor antagonist. Induces phospholipidosis and exhibits antischizophrenic activity in vivo.Product Specifications
Molecular Weight
438.89
Formula
C18H21F3N2O3S.HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
N-[4-[2-(Propylamino)ethyl)phenyl]-4-(trifluoromethoxy)-benzenesulfonamide hydrochloride
CAS Number
1783978-03-9
PubChem ID
56972219
InChI Key
UOMDLHQTLPWCCE-UHFFFAOYSA-N
SMILES
O=S(C1=CC=C(OC(F)(F)F)C=C1)(NC2=CC=C(CCNCCC)C=C2)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.78 | 20 | |
| DMSO | 43.89 | 100 |
Preparing Stock Solutions
for PNU 177864 hydrochloride
The following data is based on the product molecular weight 438.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.39 mL | 22.78 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rudmann Epididymal and systemic phospholipidosis in rats and dogs treated with DA D3 selective antagonist PNU-177864. Toxicol.Pathol. 2004 PMID: 15204974
- Vonderfecht Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrence. Toxicol.Pathol. 2004 PMID: 15204973
Product Specific Notices for PNU 177864 hydrochloride
For research use only
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