PMPA (NAALADase inhibitor)
Tocris Bioscience, part of Bio-Techne | Catalog # 1380
GCP II inhibitor
Product Description
PMPA (NAALADase inhibitor) is a highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a Ki value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).Licensing Information
Sold with the permission of AstraZeneca Ltd.Product Specifications
Molecular Weight
226.12
Formula
C6H11O7P
Storage
Desiccate at RT
Chemical Name
2-(Phosphonomethyl)pentane-1,5-dioic acid
CAS Number
173039-10-6
PubChem ID
10130754
InChI Key
ISEYJGQFXSTPMQ-UHFFFAOYSA-N
SMILES
OC(=O)CCC(CP(=O)(O)O)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.61 | 100 |
Preparing Stock Solutions
for PMPA (NAALADase inhibitor)
The following data is based on the product molecular weight 226.12
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.42 mL | 22.11 mL | 44.22 mL |
| 5 mM | 0.88 mL | 4.42 mL | 8.84 mL |
| 10 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rahn Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proc.Natl.Acad.Sci.U S A (Epub ahead of print] 2012 PMID: 23169655
- Slusher Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat.Med. 1999 PMID: 10581082
- Thomas NAALADase inhibition protects motor neurons against chronic glutamate toxicity. Eur.J.Pharmacol. 2003 PMID: 12826236
- Jackson Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase. J.Med.Chem. 1996 PMID: 8558536
Product Specific Notices for PMPA (NAALADase inhibitor)
For research use only
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