PLX 647 dihydrochloride

Name: PLX 647 dihydrochloride
Brand: Tocris Bioscience
SKU: 5102

Tocris Bioscience, part of Bio-Techne | Catalog # 5102

COA / SDS

Potent dual Fms/KIT inhibitor

Discontinued Product

5102 has been discontinued. View all Additional RTK Inhibitors products.

Key Product Details

Description:	Potent dual Fms/KIT inhibitor
Chemical Name:	5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine dihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	455.3

View Full Technical Details for PLX 647 dihydrochloride

Technical Data
Citations

Biological Activity for PLX 647 dihydrochloride

PLX 647 dihydrochloride is a potent dual KIT/Fms inhibitor (IC₅₀ values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC₅₀ values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.

Technical Data for PLX 647 dihydrochloride

M. Wt	455.3
Formula	C₂₁H₁₇F₃N₄.2HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1779796-38-1
PubChem ID	78243730
InChi Key	MVMKWLRKACAUTB-UHFFFAOYSA-N
Smiles	FC(C(C=C4)=CC=C4CNC(N=C3)=CC=C3CC2=CNC1=NC=CC=C12)(F)F.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PLX 647 dihydrochloride

References are publications that support the biological activity of the product.

Zhang Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 23493555

PLX 647 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5102

Key Product Details

Biological Activity for PLX 647 dihydrochloride

Technical Data for PLX 647 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PLX 647 dihydrochloride

Product Documents for PLX 647 dihydrochloride

COA

Certificate of Analysis

SDS

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