PKUMDL WQ 2101

Tocris Bioscience, part of Bio-Techne | Catalog # 6580

Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
Discontinued Product
6580 has been discontinued. View all Dehydrogenase Inhibitors products.

Key Product Details

Description

Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)

View all Dehydrogenase Inhibitors »

Product Description

PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.

Product Specifications

Molecular Weight

317.25

Formula

C14H11N3O6

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide

CAS Number

304481-72-9

PubChem ID

6741780

InChI Key

RABUUVVWWJCYEN-UHFFFAOYSA-N

SMILES

OC1=CC(O)=C(C(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.73 100

Preparing Stock Solutions for PKUMDL WQ 2101

The following data is based on the product molecular weight 317.25

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.76 mL 31.52 mL
5 mM 0.63 mL 3.15 mL 6.30 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PKUMDL WQ 2101

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PKUMDL WQ 2101

For research use only

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